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When mitochondria are damaged by changes in the external environment, especially by hypoxia or Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) treatment, FUNDC1 can be dephosphorylated at Ser13 by phosphoglycerate mutase family member 5 (PGAM5) phosphatase and enhance its interaction with LC3 for selective mitophagy [62, 63]
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Bmj (2011) 343:d4909
It is also a key building block for hemoglobin, which is essential for healthy red blood cells and oxygen transportation
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